Endocrine Abstracts

Introduction: In Central Europe, vitamin D deficiency is common, and a very pronounced deficiency of this vitamin is observed in obese individuals. We hypothesized that the decreased serum concentration of vitamin D might be in part due to the changed metabolism of this vitamin in adipose tissues.Methods: We assessed the expression of vitamin D 25-hydroxylase genes CYP2J2 and CYP2R1 in adipose tissues of obese and slim patients using RT...

Objective: Growth hormone (GH) is used for metabolic indications in the treatment of adult patients with GH deficiency (GHD). In addition to influencing growth processes in childhood, GH is important in regulating metabolic processes at every stage of life. GH, via insulin-like growth factor (IGF-1), has an anabolic effect on protein metabolism, also in skeletal muscles and cardiac muscle. Moreover, myokines produced by muscle fibers stimulated by muscle contraction, acting in...